Overcoming persistence challenges in allogeneic therapies for broader impact

Allogeneic therapies offer scalable solutions but must overcome biological limitations related to cell persistence and durability of effect. This session highlights approaches to extend functional longevity, integrate biomarker strategies, and design manufacturing processes that support consistent, reproducible product performance. 

Key takeaways 

• Examine factors influencing persistence in allogeneic cell therapies 

• Discuss strategies to optimize dosing and functional longevity 

• Explore biomarker approaches to monitor and predict therapeutic activity 

• Evaluate process and product design considerations for reproducibility 

• Review methods to translate persistence improvements into broader clinical impact