Fireside Chat: Bridging the gap: overcoming challenges in animal-to-human translation

Translating findings from animal models to humans remains a major challenge in advanced therapy development. This session explores methods to optimize preclinical models, leverage early human data, and implement transitional frameworks that increase efficiency and reduce risk in clinical development. 

Key Takeaways:  

• Optimize preclinical models to better predict safety and efficacy in humans 

• Integrate early human data to inform dose selection and trial design 

• Identify limitations of current animal models and mitigate translational gaps 

• Develop frameworks to de-risk early clinical programs and accelerate timelines 

• Enhance efficiency in moving therapies from translational research to clinical development