Spotlight session: Overcoming persistence in allogeneic therapies for broader impact

Allogeneic therapies face challenges in maintaining persistence and therapeutic durability in patients. This session examines approaches to improve efficacy, including the potential role of HLA matching, and evaluates strategies to maximize clinical impact. 

Key takeaways: 

• Analyze factors limiting persistence and durability in current allogeneic therapies 

• Evaluate the potential of HLA matching to enhance therapeutic efficacy 

• Discuss innovative approaches to improve long-term outcomes in patients 

• Explore strategies to optimize allogeneic therapy design for broader clinical impact 

• Assess translational considerations for advancing durable, off-the-shelf therapies