shRNA Design, Screening & Validation
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We synthesize and test five candidates per target in cultured cells using a dual-luciferase assay (gLuc normalization + cLuc functional readout), then deliver the best performer(s) with clear results and guidance for qPCR/protein confirmation—ready to package into AAV or Adenovirus.
Computationally Designed shRNA
We algorithmically design and rank shRNA against your transcripts (with isoform/UTR options and off-target minimization) so you can triage multiple targets, seed pilots, and de-risk before wet-lab work or viral packaging (AAV/Adenovirus).
Pre-Validated shRNA
Tested, proven sequences that deliver efficient gene knockdown. shRNA clones come directly from the RNAi consortium (TRC), a world class effort led by The Broad Institute. Minimal knowckdown of 70% at mRNA level in infected cells.
Computationally Designed shRNA
We algorithmically design and rank shRNA against your transcripts (with isoform/UTR options and off-target minimization) so you can triage multiple targets, seed pilots, and de-risk before wet-lab work or viral packaging (AAV/Adenovirus).
Pre-Validated shRNA
Tested, proven sequences that deliver efficient gene knockdown. shRNA clones come directly from the RNAi consortium (TRC), a world class effort led by The Broad Institute. Minimal knowckdown of 70% at mRNA level in infected cells.