Sonoma Biotherapeutics and Regeneron Announce $120M Collaboration for Cell Therapies for Autoimmune Diseases

Kadeja Johnson
30 March 2023
Cell Therapy
Clinical Trials
Collaborations, Mergers & Acquisitions
Clinical-stage biotech company Sonama Biotherapeutics  is to receive a $75 million upfront investment and an additional $45 million development milestone payment in partnership Regeneron Pharmaceuticals. This strategic partnership will apply the respective company’s scientific and clinical expertise and technology to the discovery, development and commercialization of novel regulatory T cell (Treg) therapies for autoimmune diseases.

Regeneron Pharmaceuticals, a leading biotech company that invents, develops, and commercializes medicines, has collaborated with Sonoma Biotherapeutics, a clinical-stage biotech company developing engineered regulatory T cell (Treg) therapies to treat serious autoimmune and inflammatory diseases.

 Treg cells act as sentinels that act as an indicator of the presence of diseases and rebalance the immune system. Emerging research highlights how Treg cells work directly at the site of inflammation – having the potential to create a long-lasting response.

“We are thrilled to collaborate with Regeneron with the goal of developing best-in-class Treg therapies for ulcerative colitis, Crohn’s, and other diseases,” said Jeff Bluestone, Ph.D., Co-founder and CEO of Sonoma Biotherapeutics.

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The partnership will utilize Regeneron’s industry-leading VelociSuite® technologies for the discovery and characterization of fully human antibodies and T cell receptors with Sonoma Biotherapeutics’ pioneering approach to developing and manufacturing gene-modified Treg cell therapies. 

Jeff also adds, “Regeneron has a track record of seeking out pioneers in their fields and forging successful partnerships. This collaboration will combine Regeneron’s proven technology and clinical expertise with Sonoma Bio’s proprietary Treg platform and Treg research enterprise to develop therapies that restore balance to the immune system and potentially cure disease.”

Tregs as a therapeutic modality has the ability to acquire multiple therapeutic effects, transforming treatments, within a single medicine, helping overcome the multifaceted nature of autoimmune and inflammatory diseases. 

Source: Regeneron Press Release 



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